New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy

Sharmin, Dishary; Divović, Branka; Ping, Xingjie; Cerne, Rok; Smith, Jodi L.; Rezvanian, Sepideh; Mondal, Prithu; Michelle, Meyer Jean; Kiley, Molly E.; Arnold, Leggy A.; Mian, Md Yeunus; Pandey, Kamal P.; Jin, Xiaoming; Mitrović, Jelena; Đorović, Đorđe; Lippa, Arnold; Cook, James M.; Golani, Lalit K.; Scholze, Petra; Savić, Miroslav; Witkin, Jeffrey M.

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eNauka > Results > New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy

Title:	New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy
Authors:	Sharmin, Dishary; Divović, Branka ; Ping, Xingjie; Cerne, Rok; Smith, Jodi L.; Rezvanian, Sepideh; Mondal, Prithu; Michelle, Meyer Jean; Kiley, Molly E.; Arnold, Leggy A.; Mian, Md Yeunus; Pandey, Kamal P.; Jin, Xiaoming; Mitrović, Jelena ; Đorović, Đorđe; Lippa, Arnold; Cook, James M.; Golani, Lalit K.; Scholze, Petra; Savić, Miroslav ; Witkin, Jeffrey M.;
Issue Date:	2023
Publication:	ACS Chemical Neuroscience
ISSN:	1948-7193 ACS Chemical Neuroscience Search Idenfier
Publisher:	American Chemical Society
Type:	Article
DOI:	10.1021/acschemneuro.3c00555
WoS-ID:	001158535100001
Scopus-ID:	2-s2.0-85182005653
PMID:	38175916
URI:	https://enauka.gov.rs/handle/123456789/883159 https://farfar.pharmacy.bg.ac.rs/handle/123456789/5505
Project:	Henry and Nelly Pence Foundation Trust AA029023, DA-043204, DA054177, NS-076517 Milwaukee Institute of Drug Discovery UW-Milwaukee Shimadzu Laboratory for Advanced and Applied Analytical Chemistry University of Wisconsin-Milwaukee Research Foundation
M-category:	Mp. category will be shown later

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